SLIDE 3

Sample 1

Sample 2

Sample 3

Sample 4

Slide 3 has four examples of GSK mice from Dr. David Seldin showing some patterns typical of transgenic animals and showing the variations sometimes seen in some transgenic systems. Sample 3-1 has a markedly atypical hyperplasia (MIN). Sample 3-2 has lung without metastasis. Sample 3-3 has an example of a pure squamous cell carcinoma. Sample 3-4 has a papillary carcinoma with fibrosis in the adjacent tissue.

October 3, 1999