TABLE 1:SUMMARY OF MODELS

Models

Transgene

Bitransgene/ exptal. manipulation

Species

Promoters
References
Growth Factors FGF3 (INT2) WNT1 Mouse MMTV-LTR (Kwan et al., 1992; Muller et al., 1990)
FGF7 (KGF) Mouse MMTV-LTR (Kitsberg and Leder, 1996)
HEREGULIN(NDF) myc Mouse MMTV-LTR (Krane and Leder, 1996)
HGF Mouse MT (Takayama et al., 1997)
IGFII Mouse BGL, H19 (Bates et al., 1995; Pravtcheva and Wise, 1998)
TGF a p53-172H, myc, DMBA Mouse  WAP, MMTV-LTR, MT (Coffey et al., 1994; Jhappan et al., 1990; Matsui et al., 1990; Sandgren et al., 1990; Sandgren et al., 1995)
TGF-b MMTV-infected Mouse WAP (Kordon et al., 1995)
Receptors TGFb DNIIR Mouse MMTV-LTR (Joseph et al., 1999)
ERB-B2 (neu) p53-172H Mouse,  MMTV-LTR (Guy et al., 1992; Li et al., 1997; Muller et al., 1988)
RET Mouse MMTV-LTR (Iwamoto et al., 1990)
Tpr-MET Mouse MT (Liang et al., 1996)
Signal Pathways PyV-mT Mouse MMTV-LTR (Guy et al., 1992)
RAS Mouse MMTV-LTR (Sinn et al., 1987)
Cell Cycle CYCLIN D1 Mouse MMTV-LTR (Wang et al., 1994)
MYC BCL2 Mouse MMTV-LTR, WAP (Jager et al., 1997; Stewart et al., 1984)
p53-172H, p53 Mouse WAP, Null (Donehower et al., 1992; Li et al., 1997)
SV40TAg BCL-2 Mouse WAP, C(3)1 (Furth et al., 1999; Husler et al., 1998; Maroulakou et al., 1994; Tzeng et al., 1993)
Differentiation NOTCH4(INT3) TGF b Mouse MMTV-LTR, WAP (Gallahan et al., 1996; Smith et al., 1995)
WNT 1 Mouse MMTV-LTR (Tsukamoto et al., 1988)
WNT10b Mouse MMTV-LTR (Lane and Leder, 1997)
P-CADHERIN Mouse Null (Radice et al., 1997)
Other Transgenes Stromelysin Mouse WAP (Sternlicht et al., 1999)
MTS1 Mouse MMTV-LTR (Ambartsumian et al., 1996)
Transgenic Rat Models TGF a Rat MMTV-LTR (Davies et al., 1999)
SV40Tag Rat C(3)1 (Shibata et al., 1999)
ERB-B2 (neu) Rat MMTV-LTR (Davies et al., 1999)
Miscellaneous DMBA treated rat Rat (Russo et al., 1977)
MNU treated rat Rat (Anzano et al., 1994)
MMTV infected mouse Mouse (Rehm and Liebelt, 1996)

Transplants of DMBA

treated-p53-/- mouse mammary epithelium

Mouse (Jerry et al., 1999)