|Molecular lesions causing breast cancer in human have proven to cause breast cancer in GEM.||Some molecular lesions causing breast cancer in mice have not been found in human breast cancer.|
|Similar morphological patterns of lesions appear in both species||The morphology of most mouse tumors does not resemble the common human breast cancers.|
|Development of cancer consistent with multi-hit kinetics.||Some transgenes appear to be associated with one- hit kinetics.|
|Breast cancers in both species are metastatic.||Most tumors mouse metastasize to the lung. Most human metastasize to the regional lymph nodes.|
|Both species have distinctive host responses to the cancers.||The mouse generally does not respond to its tumor with as much fibrosis and inflammation.|
|Breast cancer is frequently hormone independent.||Half of human breast cancers are hormone independent. Most mouse tumors are hormone independent.|
NOTE: The comparative pathology images can be viewed by clicking here.