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Summary
Human Mouse


2.2.6. Mammary Gland Aging

These mammary glands come from a retired breeder 77 days following weaning of the 4th litter. These glands show some regression and two squamous nodules.

     
 

The low power image of the whole mount of the #4 mammary fat pad from a retired breeder, multiparous FVB female mouse. Note the smaller mass (squamous nodule) observed in the mammary gland The larger nodule is the mammary lymph node. The squamous nodule is the most common lesion found in the retired FVB female but they are relatively rare even in this strain of mouse. Note that the rest of the mammary gland has many side branches that end in relatively sharp terminal ends. This pattern is typical of the aging, multiparous retired breeder

 

The low power image of the whole mount of the #4 mammary fat pad from a retired breeder, multiparous FVB female mouse. Note the smaller mass (squamous nodule) observed in the mammary gland The larger nodule is the mammary lymph node. The squamous nodule is the most common lesion found in the retired FVB female but they are relatively rare even in this strain of mouse. Note that the rest of the mammary gland has many side branches that end in relatively sharp terminal ends. This pattern is typical of the aging, multiparous retired breeder.

 
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The low power H&E stained image of a squamous nodule observed in the mammary gland of the retired breeder multiparous FVB female mouse. Note that the nodule is composed of both glandular and squamous epithelium and that the stroma has a dense lymphocytic infiltrate. These nodules are the most common lesions found in the retired FVB female but they are relatively rare even in this strain of mouse. They are not thought to be premalignant lesions.

 

The higher power H&E stained image of a squamous nodule observed in the mammary gland of the retired breeder multiparous FVB female mouse. Note that the nodule is composed of both glandular and squamous epithelium and that the stroma has a dense lymphocytic infiltrate. These nodules are the most common lesions found in the retired FVB female but they are relatively rare even in this strain of mouse. They are not thought to be premalignant lesions.

 

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Summary
Human Mouse