3.2.3. Comparison of Classification of Mouse Mammary Gland Proliferative Lesions

Annapolis nomenclature

Nomenclature used in the literature*

Cellular origin / Differentiation

Hyperplasia, Functional, without atypia Hyperplasia Alveolar /Ductal
Acinar Hyperplasia, Low Grade, Focal, Non-GEM Hyperplastic alveolar nodule (HAN) Alveolar
Solid Hyperplasia, Low Grade, Focal, Hormone-induced, Non-GEM Plaque/organoid/pregnancy-dependent "tumor" (Type P) Ductal
Mammary Intra-epithelial Neoplasia (MIN) No reports Alveolar /Ductal
Adenoma/Carcinoma* Adenocarcinoma Alveolar
Glandular/Acinar Type A Alveolar
Cribriform Type AB/Type B/Type L Alveolar
Papillary Type B/Type Y Alveolar
Solid Type B/Type P Alveolar/Ductal
Adenosquamous Adenoacanthoma/Pale cell tumor/Large cell tumor/Adenosquamous carcinoma Alveolar
Fibroadenoma No reports
Squamous carcinoma Molluscoid tumor/Intraductal squamous carcinoma Ductal
Adenomyoepithelioma benign/malignant Adenocarcinoma type C/Carcinosarcoma/Mixed tumor/Adenomyoepithelioma

Alveolar and/or ductal,

myoepithelial possibly with

cartilage or bone

Not otherwise specified (NOS) No reports Unknown

* alveolar or ductal origin/differentiation