TABLE OF CONTENTS

1. INTRODUCTION

2. MORPHOLOGY OF THE NORMAL MAMMARY GLAND

2.1. HUMAN

2.1.1. Development
2.1.2. Adult
2.1.3. Lactation
2.1.4. Involution/Aging

2.2. MOUSE

2.2.1. Development
2.2.2. Adult Virgin
2.2.3. Prelactation
2.2.4. Lactation
2.2.5. Involution
2.2.6. Aging

3. MORPHOLOGY OF THE ABNORMAL MAMMARY GLAND

3.1. HUMAN

3.1.1. Clinical Biology of Human Breast Cancer
3.1.2. Classification and Histology

3.2. MOUSE

3.2.1. Classification Schemes (Non-GEM)
3.2.2. Classification Schemes of Genetically Engineered Mice (GEM)
3.2.3. Comparison of Classification of Mouse Mammary Gland Proliferative Lesions

3.3. HUMAN MOUSE COMPARISONS

4. MURINE MODELS OF HUMAN BREAST CANCER

4.1. Growth Factors
4.2. Receptors
4.3. Signaling Pathways
4.4. Cell Cycle
4.5. Differentation
4.6. Other Transgenes
4.7. Miscellaneous

5. METHODS

5.1. Whole Mount and Subgross Staining
5.2. Histologic Staining
5.3. Immunohistochemistry
5.4. In Situ Hybridization
5.5. Phenotypic Markers (mouse)
5.6. Isolation of Human Lobules

6. APPENDIX

7. ACKNOWLEDGEMENTS